Amy Myers MD Complete Enzymes Review: 6 Reasons It Actually Eliminates Bloating
By Jenna Caldwell, Gut Health & Nutrition Writer · Rating: 4.8/5 ⭐⭐⭐⭐⭐ · 9 min read
On Complete Enzymes — Personal Daily Use & Formulation:
“These are my favorite digestive enzymes. I formulated these to be the best of the best. Take a look at the product ingredients and you'll see that they have an unusually complete, and very broad blend of plant and microbial-based digestive enzymes. I made sure when customizing my Complete Enzymes that they were specifically designed for those of you seeking a broad spectrum of digestive support for your individualized needs. I never travel or dine-out without taking a bottle of Complete Enzymes along with me.”
— Dr. Amy Myers, MD, Founder & CEO of Amy Myers MD®, functional medicine physician and 2x New York Times bestselling author — from the official Amy Myers MD® Complete Enzymes product page (amymyersmd.com / Fullscript)
On Why Complete Enzymes Cover a Broader Spectrum Than Most:
“Many manufacturers skimp on enzyme types and strains to save on costs. I made sure when customizing my Complete Enzymes that they were specifically designed for those of you with digestive issues, food sensitivities, and nutrient absorption challenges. These enzymes break down everything from protein and protein peptides, to carbohydrates, disaccharides, sugars, lipids/fats, and even vegetable fibers.”
— Dr. Amy Myers, MD, from the Amy Myers MD® Complete Enzymes Chewable product description — official brand formulation statement (amymyersmd.com)
I'd Tried Five Digestive Enzymes Before This One. None of Them Worked Like This.
My bloating history is long and boring: post-meal distension that made me look three months pregnant by dinner, the kind of gas that made dinner with other people an exercise in strategic seating, and a general sense of digestive fragility that had me avoiding entire food categories not because I had diagnosed intolerances but because the reaction was unpredictable enough that it wasn't worth the risk. I'd tried five different digestive enzyme supplements over the years. All of them helped a little. None of them solved it.
Amy Myers MD Complete Enzymes was different — not in a dramatic, first-dose kind of way, but consistently different across weeks of use. The reason, I eventually figured out, was the enzyme spectrum. Most of the products I'd tried had 6–8 enzymes. The Complete Enzymes has 19+, targeting substrate categories that the cheaper products don't touch. That specificity of coverage is why it works where others didn't — and it's the foundation for all six reasons I'm laying out below.
What Is Amy Myers MD Complete Enzymes?
Amy Myers MD Complete Enzymes is a physician-formulated, full-spectrum digestive enzyme supplement containing 19+ distinct enzymes organized into five functional categories: carbohydrate-specific enzymes, sugar-specific enzymes, vegetable and plant fiber enzymes, protein and peptide enzymes, and specialized enzymes including Serratia peptidase and Lysozyme.
The product is available in two forms: a capsule (120 capsules, 2 per serving, 60 servings) and a chewable tablet (180 tablets). The capsule version includes Lysozyme from egg white; the chewable version omits it for those who prefer a vegan-friendly option. Both are gluten-free, dairy-free, and soy-free.
The supplement is priced at approximately $50 for 120 capsules (60 servings). Available at amymyersmd.com.
💊 Amy Myers MD Complete Enzymes — At a Glance
6 Reasons It Actually Eliminates Bloating
① It Covers 19+ Enzymes Across Every Major Food Category — Not Just Protein and Carbs
Most digestive enzyme supplements target protein (protease) and starch (amylase), and maybe add lipase for fats. The Complete Enzymes goes further: separate enzymes for lactose (lactase), sucrose (sucrase), maltose (maltase), plant fibers (cellulase, hemicellulase, beta-glucanase), galactooligosaccharides found in legumes (alpha-galactosidase — the same compound in Beano), and two additional carbohydrate-specific enzymes beyond basic amylase. This coverage matters because bloating has multiple substrates. If you bloat from onions and garlic (fructooligosaccharides), from beans (galactooligosaccharides), from dairy (lactose), from wheat (both starch and gluten peptides), and from high-fiber vegetables (cellulose) — one enzyme formula that covers all of these is going to outperform a formula that only handles two or three. The completeness is the point.
② DPP-IV Specifically Addresses Gluten Peptides — A Breakthrough for Accidental Exposure
DPP-IV (dipeptidyl peptidase IV) is an enzyme that targets the proline-rich peptide bonds found in gluten and casein — the proteins that conventional proteases don't fully break down. For people who are gluten-sensitive (not celiac — DPP-IV is not a celiac treatment) but eat gluten-free most of the time and occasionally face unavoidable cross-contamination at restaurants or social events, DPP-IV is a meaningful practical tool. The Complete Enzymes Protease/Peptidase Complex contains DPP-IV activity within its 30,000 HUT protease dose. I went from dreading restaurant meals where gluten cross-contamination was probable to using two Complete Enzymes capsules before the meal as a consistent management strategy. The post-meal reaction I used to get — the next-morning bloating and gut discomfort that followed accidental gluten — was significantly reduced. It's not a cure and it's not a replacement for gluten avoidance, but it's the most meaningful practical tool I've found for managing real-world gluten exposure.
③ Serratia Peptidase (Enteric-Coated) Supports Intestinal Repair — Not Just Digestion
This is the enzyme that distinguishes Complete Enzymes from every general-purpose digestive enzyme I've tried. Serratia peptidase (serrapeptase) is a proteolytic enzyme that, when delivered to the small intestine rather than broken down in the stomach, supports the breakdown of damaged tissue proteins, biofilms, and mucus — and helps maintain the body's normal inflammatory response in the gut lining. The “enteric-coated” specification matters: an un-coated serrapeptase is degraded by stomach acid and never reaches the intestine. The 2,500 SPU dose in the Complete Enzymes is enteric-coated, which means it bypasses the stomach and acts where it needs to act. For anyone with leaky gut or intestinal inflammation, this is not a standard digestive enzyme feature — it's a targeted intestinal support mechanism that most enzyme products don't include.
④ Results Are Noticeable Within Hours — Not Weeks
Unlike collagen or probiotics, digestive enzymes work on each specific meal. There's no cumulative tissue-change timeline — the enzymes either break down the food in that meal or they don't. The first time I took Complete Enzymes before a dinner that would normally guarantee post-meal bloating (a large salad with chickpeas, onions, and a Caesar dressing with a hidden dairy component), I noticed the difference the same evening. The usual distension didn't develop. The post-meal heaviness was significantly reduced. This immediate-feedback loop is what makes digestive enzymes both easy to evaluate and easy to maintain compliance with — you know within hours whether they worked, which makes you want to take them consistently. Most gut supplements require weeks before you can judge efficacy; this one shows its hand in the same meal.
⑤ Lysozyme Supports Gut Microbiome Balance — An Underappreciated Inclusion
Lysozyme is an antimicrobial enzyme found naturally in saliva, tears, and breast milk. In the capsule version of Complete Enzymes (10,000 SU per serving), it acts in the gut to help maintain a healthy balance between beneficial and pathogenic bacteria by degrading the cell walls of certain gram-positive bacteria. For people with gut dysbiosis, SIBO, or Candida overgrowth — conditions that commonly co-occur with leaky gut — Lysozyme provides a supplementary layer of microbiome regulation that goes beyond what standard digestive enzymes offer. It's not present in the Chewable version (relevant for vegans), but in the capsule formula it's one of the more thoughtfully included ingredients that most competitors don't feature.
⑥ It Works as Part of the Gut-Healing Stack — Not as a Standalone Fix
On its own, Complete Enzymes reduces bloating and improves digestion meal-by-meal — that's real and valuable. But the product is designed within The Myers Way® gut-healing protocol to work alongside Leaky Gut Revive (gut lining repair) and Probiotics (microbiome restoration). The logic is sequential: Complete Enzymes reduces the inflammatory load from poorly digested food particles; Leaky Gut Revive repairs the intestinal lining that improperly digested proteins were permeating; Probiotics restore the bacterial ecosystem that should be helping with digestion in the first place. I noticed this synergy clearly after three months of using all three together — my food sensitivities had broadened, meaning I could eat more things that had previously troubled me. The enzymes alone didn't produce that; the combined protocol did. Complete Enzymes is the most immediately noticeable piece of the stack, but it works best in the context it was designed for.
Bloating after every meal isn't your food intolerance. It might be a missing enzyme.
Amy Myers MD Complete Enzymes — 19+ enzymes covering proteins, carbs, sugars, fats, fiber, and gluten peptides. DPP-IV + Serratia peptidase. Full-spectrum gut support. amymyersmd.com.
Week by Week Experience
📅 Days 1–3 — Immediate Change in Post-Meal Comfort
I started Complete Enzymes on a Thursday and by Sunday I had a clear read on whether they were working. I took two capsules before each of four different meals — a salad, a higher-fat dinner, a legume-heavy lunch, and a restaurant meal with ambiguous ingredients. The bloating that typically followed the salad and the legume meal was dramatically reduced. The restaurant meal — which usually produced next-morning gut discomfort that I attributed to hidden gluten — produced less of the usual reaction. By day three I was already confident this was going to be different from the other enzymes I'd tried. The speed of response was unlike any supplement I've used — digestive enzymes either work in the meal or they don't, and these clearly did.
📅 Weeks 2–4 — Food Confidence Returned
By week two, I started eating foods I'd been avoiding — raw onions, lentils, broccoli in larger amounts. With two capsules before the meal, none of them produced the bloating they used to. By week three, I was eating differently in social situations because I was no longer pre-calculating the digestive fallout of everything I ordered. This is a quality-of-life change that's hard to quantify but easy to notice: I stopped being anxious about eating in public. By week four, the baseline post-meal comfort had improved even on days I ate foods that had previously been reliably problematic.
📅 Month 2 — The Accidental Test Confirms Everything
At the six-week mark, I ran out of Complete Enzymes and didn't reorder immediately — I wanted to see what happened. Within four days, the bloating was back. Not catastrophically, but consistently — the same foods that I'd been eating without issue for six weeks started producing discomfort again. I reordered and the improvement returned within two days. This A/B confirmation was cleaner than anything I'd observed during the initial period of use. The enzymes were doing the work on every meal, and removing them removed the result. I now keep a backup container so I don't run out.
What It Does Well
- 19+ enzymes covering every major food substrate: Protein, carbohydrates, disaccharides, sugars, fats, plant fibers, and gluten peptides — the most complete coverage of any enzyme product I've used.
- DPP-IV for gluten peptide breakdown: A practical tool for gluten-sensitive (non-celiac) individuals dealing with accidental exposure or cross-contamination.
- Enteric-coated Serratia peptidase: Intestinal support mechanism beyond digestion — supports healthy inflammatory response in the gut lining. Rare in consumer enzyme products.
- Immediate results: Effects are meal-specific and noticeable within hours, not weeks — making compliance easy and efficacy easy to evaluate.
- Physician-formulated within a gut protocol: Designed to work within The Myers Way® gut-healing stack alongside Leaky Gut Revive and Probiotics — not a standalone product without context.
- Chewable option available: The Complete Enzymes Chewable is vegan-friendly (no Lysozyme) and provides the same core enzyme spectrum in a different delivery format.
- GMP-certified, third-party tested: Consistent quality verification across the Amy Myers MD line.
What Could Be Better
- Price is premium: At ~$50 for 60 servings ($0.83/serving), it's the most expensive digestive enzyme on this comparison list. Enzymedica Digest Gold and NOW Super Enzymes deliver comparable core coverage at significantly lower price points. The premium is justified by the Serratia peptidase and Lysozyme inclusions — but only if you need those.
- Capsule version contains egg-derived Lysozyme: Not vegan, not suitable for egg allergy. The Chewable version solves this, but it's worth knowing which version you're ordering.
- Two capsules per serving adds up quickly: At 2 capsules per meal and 3 meals per day, one 120-capsule container lasts 20 days for full daily use. Most people use them selectively (larger meals, restaurant meals) which extends it considerably — but it's worth calculating your actual use case before assuming the 60-serving claim applies to you.
- Not a substitute for dietary changes: The enzymes reduce the inflammatory load from incompletely digested food, but they don't repair a leaky gut on their own. Within The Myers Way® protocol, they work alongside Leaky Gut Revive and dietary modification — using them without addressing root causes produces improvement, not resolution.
Complete Enzymes vs Competitors
| Brand | # Enzymes | DPP-IV | Serrapeptase | Lysozyme | Fiber enzymes | GF / DF | $/serving |
|---|---|---|---|---|---|---|---|
| Amy Myers MD ⭐ | 19+ | ✅ Yes | ✅ Enteric-coated | ✅ (capsule) | ✅ 6 types | ✅ / ✅ | ~$0.83 |
| Enzymedica Digest Gold | 9 | ❌ No | ❌ No | ❌ No | Partial (2 types) | ✅ / ✅ | ~$0.50 |
| NOW Super Enzymes | 5 | ❌ No | ❌ No | ❌ No | ❌ No | ✅ / ❌ (ox bile) | ~$0.18 |
| Pure Encapsulations Digestive Enzymes Ultra | 14 | ✅ Yes | ❌ No | ❌ No | ✅ 4 types | ✅ / ✅ | ~$0.70 |
| Thorne Bio-Gest | 4 | ❌ No | ❌ No | ❌ No | ❌ No | ✅ / ✅ | ~$0.42 |
Amy Myers MD Complete Enzymes is the clear leader on enzyme breadth, gluten-specific DPP-IV coverage, intestinal support via enteric-coated Serratia peptidase, and microbiome management via Lysozyme. The closest competitor on spectrum breadth is Pure Encapsulations Digestive Enzymes Ultra — strong on DPP-IV and fiber enzymes but missing the Serratia peptidase and Lysozyme inclusions. For general-purpose bloating relief at lower cost, Enzymedica Digest Gold covers the basics well. For gut-healing protocol users who need the full intestinal support toolkit, Amy Myers MD is in a different category.
Who Should Try It
- Chronic bloaters who have tried basic digestive enzymes without success — if a 5–8 enzyme product hasn't solved it, the issue may be substrates that narrow-spectrum enzymes don't cover. The Complete Enzymes' breadth addresses this systematically.
- Anyone following The Myers Way® gut-healing protocol — Complete Enzymes is the foundation of the protocol's digestion pillar, working alongside Leaky Gut Revive and Probiotics as part of the full gut-healing stack.
- Gluten-sensitive (non-celiac) people who eat out or face frequent cross-contamination — the DPP-IV inclusion makes this the most practical tool I've found for real-world gluten exposure management.
- People with leaky gut and intestinal inflammation — the enteric-coated Serratia peptidase provides intestinal anti-inflammatory support that standard digestive enzyme products don't include.
- Anyone over 40 with declining enzyme production — digestive enzyme production declines with age; supplementing with a broad-spectrum product addresses this directly.
Who Should Skip It
- Celiac disease patients — DPP-IV is not a celiac treatment and does not prevent the autoimmune response. Complete Enzymes should not be used as a substitute for strict gluten avoidance in diagnosed celiac disease.
- If you have an egg allergy — the capsule version contains Lysozyme from egg white. Use the Chewable version, which excludes Lysozyme.
- Budget-first buyers who need basic bloating relief — Enzymedica Digest Gold at ~$0.50/serving provides solid core coverage at 40% less per serving. The premium features of Complete Enzymes (Serratia peptidase, Lysozyme, full fiber enzyme spectrum) are worth the price for gut-healing protocol users but may not be necessary for general use.
- If you're not willing to take them before every meal — digestive enzymes are a before-meal habit, not a morning supplement. The compliance pattern is different from other supplements, and if pre-meal dosing doesn't fit your routine, you'll underuse the product.
⭐ Final Verdict: Amy Myers MD Complete Enzymes Review
After trying five other digestive enzyme products over as many years, the Complete Enzymes is the first one that solved the problem rather than partially managing it — and the reason is the breadth of coverage. Nineteen enzymes covering every major food substrate, DPP-IV for gluten peptides, enteric-coated Serratia peptidase for intestinal support, and Lysozyme for microbiome balance. The accidental A/B test at six weeks — running out and watching the bloating return within four days — confirmed it wasn't placebo.
The limitations are honest: it's priced at the premium end, the egg-derived Lysozyme makes the capsule version non-vegan, and it works best as part of the full gut-healing protocol rather than as a standalone fix. But for the target user — someone with persistent bloating, food sensitivities, leaky gut, or an autoimmune condition — the Complete Enzymes is the most comprehensive digestive enzyme supplement I've tested.
Rating: 4.8 / 5.0 — Available at amymyersmd.com.
19 enzymes. Every food category. Real bloating relief — starting with your next meal.
Amy Myers MD Complete Enzymes — DPP-IV, enteric-coated Serratia peptidase, Lysozyme. The most complete digestive enzyme formula in functional medicine. amymyersmd.com.
Frequently Asked Questions
What does Amy Myers MD Complete Enzymes do?
Breaks down proteins, carbohydrates, sugars, fats, and plant fibers across 19+ enzymes. Includes DPP-IV for gluten peptide digestion, enteric-coated Serratia peptidase for intestinal support, and Lysozyme for microbiome balance. Reduces bloating, improves nutrient absorption, and supports gut health.
When should I take Amy Myers MD Complete Enzymes?
2–5 minutes before meals, or immediately before eating. 2 capsules per serving. 120 capsules = 60 servings. Most users take them before complex or larger meals; some take them before every meal for consistent digestive support.
Does Amy Myers MD Complete Enzymes help with gluten intolerance?
Yes — DPP-IV enzyme supports breakdown of gluten peptides from accidental exposure. Not a celiac treatment — does not prevent the autoimmune response. Valuable for gluten-sensitive (non-celiac) individuals managing cross-contamination.
What makes Amy Myers MD Complete Enzymes different?
19+ enzymes vs 5–9 in most competitors. Includes DPP-IV (gluten), enteric-coated Serratia peptidase (intestinal repair support), and Lysozyme (microbiome balance) — features absent from most consumer enzyme products.
Is Amy Myers MD Complete Enzymes vegan and gluten-free?
Capsule version: gluten-free, dairy-free, soy-free — but contains Lysozyme from egg white (not vegan, not for egg allergy). Chewable version: fully plant-based, vegan-friendly, no Lysozyme. Both versions are GF/DF/SF.
How long before I see results?
Bloating relief: same meal (hours, not weeks). Enzymes work meal-specific — you can evaluate results after your first few uses. Sustained benefits (reduced food sensitivities, improved nutrient absorption) develop over several weeks of consistent use.
What is Serratia peptidase in Complete Enzymes?
A proteolytic enzyme delivered enteric-coated (bypasses stomach acid) that supports healthy inflammatory response and tissue repair in the small intestine. 2,500 SPU per serving. Particularly relevant for leaky gut and intestinal inflammation.
How does Amy Myers MD Complete Enzymes compare to Digest Gold?
Amy Myers MD: 19+ enzymes, DPP-IV, Serratia peptidase, Lysozyme, ~$0.83/serving. Enzymedica Digest Gold: 9 enzymes, no DPP-IV, no Serratia peptidase, ~$0.50/serving. Digest Gold is better value for general bloating relief; Amy Myers MD is stronger for gut-healing protocol users needing full intestinal support. Available at amymyersmd.com →
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